![]() Water accounts for up to 99% of saliva composition. Submandibular glands are responsible for the production of about 25% of the fluid, while sublingual glands produce the remaining 5% (submandibular/sublingual saliva - SMS). About 70% of whole saliva (WS) is produced by parotid glands (parotid saliva, PS). Saliva can be easily collected, in a non-invasive way, and stored for the analysis with a minimum handling, when compared to other biofluids. Potential applications of salivary biomarkers include early diagnosis, prognosis, follow-up and management of oral and systemic diseases. Saliva is a biofluid potentially useful for new approaches based on the quantitative and qualitative analysis of biomarkers. Local Health Authority of Reggio Emilia (IRCCS), Italy ![]() ![]() University Hospital of Parma, Department of Medicine and Surgery, Italy ![]()
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